Science
Vaccine platform
Ambifect® protein therapeutic platform
We use Akston’s Ambifect® Fc-fusion platform. This versatile platform supports species-specific development, tailored interaction with the immune system, delivery of customized agents for a wide variety of diseases, and increased duration of action.
Ambifect® platform advantages
The Ambifect® platform’s versatility enables us to customize how a candidate engages with its disease target and interacts with the immune system.
Therapies developed using the Ambifect® platform can be manufactured with the industry-standard techniques and equipment used for therapeutic antibody production. Promising candidates can be designed, synthesized, and tested to optimize performance in a comparatively rapid process which significantly reduces development time and cost.
Ambifect® platform enables pipeline expansion in therapeutic vaccines against protein targets implicated in disease and in long-duration protein drugs allowing us to produce therapeutics that address a wide variety of disease conditions.
Biomarkers
Human humoral immunome biomarkers
We use pep-seq for mapping antibody responses against human and viral proteins in patients of neurological diseases and cancer to determine their possible protective role, by correlating their levels with clinical parameters. Confirming this support the use of vaccines to boost a humoral response. We use the results to guide the epitope selection for our vaccine design to treat and prevent those pathologies.
PepSeq immune profiling technology
PepSeq Immune Profiling against 100,000s of human proteins and viral epitopes
Neuron-derived extracellular vesicles (NDEs)
We use NeuroDex’s ExoSORT technology to isolate NDEs from plasma and analyze teir content of neurodegenerative proteins and viral nucleic acids. ExoSORT is an immunoaffinity capture platform that uses proprietary recombinant antibodies against neuron-specific surface proteins that allows specific isolation of neuron-derived extracellular vesicles, providing a unique neurological liquid biopsy. ExoSORT was optimized and qualified using multiple methods, including unbiased proteomic, RNAseq, and spike-in recovery experiments. ExoSORT is used to identify brain pathology and monitor treatment response.
Neurons release exosomes carrying proteins and nucleic acids into the circulation. ExoSORT allows the isolation and analysis of NDEs from plasma.
